List I:
Substances identified as endocrine disruptors at EU level
This list contains substances that have undergone an evaluation of endocrine disrupting properties, as regulated in the EU in PPPR, BPR or REACH, and which are identified and legally adopted as endocrine disruptors.
Currently (April 2022) no compounds are identified/regulated for endocrine disrupting properties under the Cosmetic Products Regulation although the Commission is performing a targeted literature screening of selected compounds.
Latest update 2023/11
| Name and abbreviation Sortér faldende | CAS no. | EC / List no. | Health Effects | Environmental Effects | Status | Regulatory Field |
|---|---|---|---|---|---|---|
| (±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-(4-MBC) | 36861-47-9 | 253-242-6 | Yes | Yes | Health candidate list year: 2022 Commission EDC list year*: 2019 |
REACH, Cosmetics |
| (1R,3E,4S)-1,7,7-trimethyl-3-(4- methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 95342-41-9 | Yes | Health candidate list year: 2022 |
REACH | ||
| (1R,3Z,4S)-1,7,7-trimethyl-3-(4- methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 852541-21-0 | Yes | Health candidate list year: 2022 |
REACH | ||
| (1R,4S)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 741687-98-9 | Yes | Health candidate list year: 2022 |
REACH | ||
| (1S,3E,4R)-1,7,7-trimethyl-3-(4- methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 852541-30-1 | Yes | Health candidate list year: 2022 |
REACH | ||
| (1S,3Z,4R)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 852541-25-4 | Yes | Health candidate list year: 2022 |
REACH | ||
| (3E)-1,7,7-trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one (4-MBC) | 1782069-81-1 | Yes | Health candidate list year: 2022 |
REACH | ||
| 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptan-2-one; 3-BC | 15087-24-8 | 239-139-9 | Yes |
Environmental candidate list year: 2019 |
REACH | |
| 14-(nonylphenoxy)-3,6,9,12-tetraoxatetradecan-1-ol | 26264-02-8 | 247-555-7 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 17-(4-nonylphenoxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol | 34166-38-6 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| 2-(4-nonylphenoxy)ethanol | 104-35-8 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| 2-[2-(4-nonylphenoxy)ethoxy]ethanol | 20427-84-3 | 243-816-4 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethanol | 7311-27-5 | 230-770-5 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethanol | 2315-67-5 | 621-345-9 | Yes |
Environmental candidate list year: 2012 Environmental authorisation list year: 2019 |
REACH | |
| 2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol | 1119449-37-4 | 687-832-3 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethanol | 2315-61-9 | Yes |
Environmental candidate list year: 2012 Environmental authorisation list year: 2019 |
REACH | ||
| 2-{2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethoxy}ethanol | 1119449-38-5 | 687-833-9 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 20-(4-nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol | 27942-27-4 | 248-743-1 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 20-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-3,6,9,12,15,18-hexaoxaicosan-1-ol | 2497-59-8 | 219-682-8 | Yes |
Environmental candidate list year: 2012 Environmental authorisation list year: 2019 |
REACH | |
| 23-(nonylphenoxy)-3,6,9,12,15,18,21-heptaoxatricosan-1-ol | 27177-05-5 | 248-293-6 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 26-(4-Nonylphenoxy)-3,6,9,12,15,18,21,24- octaoxahexacosan -1-ol | 14409-72-4 | 604-395-6 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol | 26571-11-9 | 247-816-5 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 3,6,9,12-Tetraoxatetradecan-1-ol, 14-(4-nonylphenoxy)- | 20636-48-0 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| 4-(1-ethyl-1-methylhexyl)phenol | 52427-13-1 | 257-907-1 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| 4-(1-Ethyl-1,3-dimethylpentyl)phenol | 186825-36-5 | 635-389-1 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| 4-(1-Ethyl-1,4-dimethylpentyl)phenol | 142731-63-3 | 635-391-2 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| 4-(1,1,3,3-tetramethylbutyl)phenol | 140-66-9 | 205-426-2 | Yes |
Environmental candidate list year: 2011 |
REACH | |
| 4-(1,1,5-Trimethylhexyl)phenol | 521947-27-3 | Yes |
Environmental candidate list year: 2012 |
REACH | ||
| 4-(2-methylhexan-2-yl)phenol | 30784-31-7 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(2,2-dimethylpentan-3-yl)phenol | 861010-65-3 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(2,3-dimethylpentan-2-yl)phenol | 861011-60-1 | 854-135-2 | Yes |
Environmental candidate list year: 2017 |
REACH | |
| 4-(2,3,3-trimethylbutan-2-yl)phenol | 72861-06-4 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(2,4-dimethylpentan-2-yl)phenol | 33104-11-9 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(2,4-dimethylpentan-3-yl)phenol | 1824346-00-0 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(3-ethylheptan-2-yl)phenol | 186825-39-8 | 635-696-0 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| 4-(3-ethylpentan-3-yl)phenol | 37872-24-5 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(3-ethylpentyl)phenol | 911370-98-4 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(3-methylhexan-2-yl)phenol | 854904-93-1 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(3-methylhexan-3-yl)phenol | 30784-32-8 | 854-958-7 | Yes |
Environmental candidate list year: 2017 |
REACH | |
| 4-(3-methylhexyl)phenol | 102570-52-5 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(3,3-dimethylpentan-2-yl)phenol | 911371-06-7 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(4-methylhexan-2-yl)phenol | 71945-81-8 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(4-methylhexyl)phenol | 1139800-98-8 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(4,4-dimethylpentan-2-yl)phenol | 911371-07-8 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(5-methylhexan-2-yl)phenol | 857629-71-1 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(5-methylhexan-3-yl)phenol | 854904-92-0 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(5-methylhexyl)phenol | 100532-36-3 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(heptan-2-yl)phenol | 6863-24-7 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(heptan-3-yl)phenol | 6465-74-3 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-(heptan-4-yl)phenol | 6465-71-0 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| 4-heptylphenol | 1987-50-4 | 217-862-0 | Yes |
Environmental candidate list year: 2017 |
REACH | |
| 4-isododecylphenol | 27459-10-5 | 608-055-8 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH |
| 4-Nonylphenol, branched, ethoxylated | 127087-87-0 | 932-098-4 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 4-Nonylphenol, branched, ethoxylated 1 - 2.5 moles ethoxylated | 127087-87-0 | 500-315-8 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 4-Nonylphenol, ethoxylated 1 - 2.5 moles ethoxylated | 26027-38-3 | 500-045-0 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| 4-t-Nonylphenol-diethoxylate | 156609-10-8 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| 4-tert-butylphenol | 98-54-4 | 202-679-0 | Yes |
Environmental candidate list year: 2019 CoRAP list year: 2014 |
REACH | |
| 4,4'-(1-methylpropylidene)bisphenol: Bisphenol B | 77-40-7 | 201-025-1 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH |
| 4,4'-isopropylidenediphenol; Bisphenol A | 80-05-7 | 201-245-8 | Yes | Yes | Health candidate list year: 2017 Environmental candidate list year: 2018 |
REACH |
| 4,4'-sulphonyldiphenol; Bisphenol S | 80-09-1 | 201-250-5 | Yes | Yes | Health candidate list year: 2023 Environmental candidate list year: 2023 |
REACH |
| Benzyl butyl phthalate (BBP) | 85-68-7 | 201-622-7 | Yes | Health candidate list year: 2017 |
REACH | |
| Bis(2-ethylhexyl) phthalate (DEHP) | 117-81-7 | 204-211-0 | Yes | Yes | Health candidate list year: 2014 Environmental candidate list year: 2017 |
REACH |
| Butyl 4-hydroxybenzoate; Butylparaben | 94-26-8 | 202-318-7 | Yes | Health candidate list year: 2020 Commission EDC list year*: 2019 |
REACH, Cosmetics | |
| Cholecalciferol | 67-97-0 | 200-673-2 | Yes | Yes | Biocides | |
| Dibutyl phthalate (DBP) | 84-74-2 | 201-557-4 | Yes | Health candidate list year: 2017 |
REACH | |
| Dicyclohexyl phthalate (DCHP) | 84-61-7 | 201-545-9 | Yes | Health candidate list year: 2018 CoRAP list year: 2017 |
REACH | |
| Diisobutyl phthalate (DIBP) | 84-69-5 | 201-553-2 | Yes | Health candidate list year: 2017 |
REACH | |
| Formaldehyde, reaction products with branched and linear heptylphenol, carbon disulfide and hydrazine | 93925-00-9 | 300-298-5 | Yes |
Environmental candidate list year: 2018 Environmental authorisation list year: 2022 |
REACH | |
| Formaldehyde, reaction products with phenol heptyl derivs. and 1,3,4-thiadiazolidine-2,5-dithione | 1471311-26-8 | Yes |
Environmental candidate list year: 2018 Environmental authorisation list year: 2022 |
REACH | ||
| Isobutyl 4-hydroxybenzoate; Isobutylparaben | 4247-02-3 | 224-208-8 | Yes | Yes | Health candidate list year: 2023 Environmental candidate list year: 2023 |
REACH, Food Contact Materials, Cosmetics |
| Isononylphenol | 11066-49-2 | 234-284-4 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| Isononylphenol, ethoxylated | 37205-87-1 | 609-346-2 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Mancozeb | 8018-01-7 | Yes | Yes | Pesticides | ||
| Nonylphenol | 25154-52-3 | 246-672-0 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| Nonylphenol, branched, ethoxylated | 68412-54-4 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| Nonylphenol, branched, ethoxylated 1 - 2.5 moles ethoxylated | 68412-54-4 | 500-209-1 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated | 9016-45-9 | 500-024-6 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated (10-EO) | 9016-45-9 | 931-755-2 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated (15-EO) | 9016-45-9 | 931-756-8 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated (6,5-EO) | 9016-45-9 | 931-753-1 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated (8-EO) | 9016-45-9 | 931-754-7 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Nonylphenol, ethoxylated (EO = 10) | 939-993-9 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| Nonylphenol, ethoxylated (EO = 4) | 939-975-0 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| Nonylphenol, ethoxylated (polymer) | 938-618-6 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| Nonylphenolpolyglycolether | 932-998-7 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| p-(1-methyloctyl)phenol | 17404-66-9 | 241-427-4 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| p-(1,1-dimethylheptyl)phenol | 30784-30-6 | 250-339-5 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| p-(1,1-dimethylpropyl)phenol | 80-46-6 | 201-280-9 | Yes |
Environmental candidate list year: 2017 CoRAP list year: 2014 |
REACH | |
| p-isononylphenol | 26543-97-5 | 247-770-6 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| p-nonylphenol | 104-40-5 | 203-199-4 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| Phenol, (tetrapropenyl) derivatives | 74499-35-7 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH | |
| Phenol, 4-(1-ethyl-1,2-dimethylpropyl)- | 30784-27-1 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| Phenol, 4-dodecyl, branched | 210555-94-5 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH | |
| Phenol, 4-isododecyl- | 27147-75-7 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH | |
| Phenol, 4-nonyl-, branched | 84852-15-3 | 284-325-5 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| Phenol, 4-nonyl-, phosphite (3:1) | 3050-88-2 | 608-492-4 | Yes |
Environmental candidate list year: 2019 |
REACH | |
| Phenol, 4-tert-heptyl- | 288864-02-8 | Yes |
Environmental candidate list year: 2017 |
REACH | ||
| Phenol, dodecyl-, branched | 121158-58- | 310-154-3 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH |
| Phenol, heptyl derivs | 72624-02-3 | 276-743-1 | Yes |
Environmental candidate list year: 2017 |
REACH | |
| Phenol, nonyl-, branched | 90481-04-2 | 291-844-0 | Yes |
Environmental candidate list year: 2012 |
REACH | |
| Phenol, p-isononyl-, phosphite (3:1) | 31631-13-7 | Yes |
Environmental candidate list year: 2019 |
REACH | ||
| Phenol, p-sec-nonyl-, phosphite | 106599-06-8 | Yes |
Environmental candidate list year: 2019 |
REACH | ||
| Phenol, tetrapropylene- | 57427-55-1 | Yes | Yes | Health candidate list year: 2021 Environmental candidate list year: 2021 |
REACH | |
| Poly (oxy-1,2-ethanediyl), alpha -(nonylphenyl)-omega-hydroxy-, branched | 68412-54-4 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | ||
| Poly(oxy-1,2-ethanediyl), a-(nonylphenyl)-w-hydroxy- | 9016-45-9 | 931-562-3 | Yes |
Environmental candidate list year: 2013 Environmental authorisation list year: 2019 |
REACH | |
| Poly(oxy-1,2-ethanediyl), α-[(1,1,3,3-tetramethylbutyl)phenyl]-ω-hydroxy- | 9036-19-5 | Yes |
Environmental candidate list year: 2012 Environmental authorisation list year: 2019 |
REACH | ||
| Polyethylene glycol p-(1,1,3,3-tetramethylbutyl)phenyl ether | 9002-93-1 | Yes |
Environmental candidate list year: 2012 Environmental authorisation list year: 2019 |
REACH | ||
| Tris (4-nonylphenol, branch) phosphorous acid ester | Yes |
Environmental candidate list year: 2019 |
REACH | |||
| Tris(nonylphenyl) phosphite | 26523-78-4 | 247-759-6 | Yes |
Environmental candidate list year: 2019 |
REACH |
*Commission EDCs cosmetics priority list year